S-adenosyl-L-methionine 1,4-butane disulfonate

Ademetionine* (Ademetionine*)

Pharmacological groups


  • Antidepressants
  • Hepatoprotectors



Intrahepatic cholestasis, liver damage: toxic, including alcoholic, viral, medicinal (antibiotics, antitumor, antituberculosis, antiviral drugs, tricyclic antidepressants, oral contraceptives); cirrhotic and precirrhotic conditions; encephalopathy, incl. associated with liver failure (alcoholic, etc.); depressive and withdrawal syndrome.


Hypersensitivity, pregnancy (I and II trimesters).

Use during pregnancy and lactation

Contraindicated in pregnancy (I and II trimesters). At the time of treatment should stop breastfeeding.

Side effects

From the digestive tract: when taken orally – heartburn, pain or discomfort in the epigastric region, dyspepsia.

Other: allergic reactions.

Precautionary measures

Given the tonic result, it is not suggested to take before bedtime. Treatment is carried out under medical supervision. During long-term therapy, it is necessary to determine the content of urea and creatinine in the blood serum. In cirrhotic and precirrhotic conditions against the background of hyperazotemia, the level of nitrogen in the blood should be carefully monitored.

special instructions

The solution is prepared immediately before use; the tablet is removed from the package before taking. If the color of the lyophilized powder or tablet changes color, you should refrain from using them.

Storage conditions of the preparation

At a temperature of 2–8 °C.

Keep out of the reach of children.


Expiry date of the drug

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