Myasthenia gravis is a progressive disease that occurs as a result of a violation of immune mechanisms and is characterized by pathological muscle fatigue due to impaired neuromuscular conduction.
Causes of myasthenia gravis
It is difficult to establish the exact cause, a genetic predisposition is essential.
Types of myasthenia
Various classifications of myasthenia have been proposed, the most common is the division into generalized and local (pharyngeal-facial, pseudobulbar syndrome and ophthalmic).
The main symptoms of myasthenia gravis
The main clinical manifestation of myasthenia gravis is the syndrome of pathological muscle fatigue (increased manifestations of myasthenia gravis after exercise and decrease after rest).
Treatment of myasthenia gravis
With modern methods of diagnosis and treatment, mortality has become minimal – less than 1%, within 80% of patients achieve complete / incomplete remission during treatment. But still, the disease is chronic, serious and requires careful monitoring and treatment. Use conservative and surgical treatment.
Articles from the forum on the topic ” Myasthenia gravis “
myasthenia gravis what is it? Is it even possible to live with this?
Answer #1
Myasthenia, Myasthenia Gravis (from Greek μύς – muscle and Greek ἀσθένεια – impotence, weakness) is a neuromuscular disease characterized by pathological, rapid fatigue of striated muscles.
Previously, myasthenia gravis was a serious disease with a high mortality rate of 30-40%. However, with modern methods of diagnosis and treatment, mortality has become minimal – less than 1%, about 80% achieve complete / incomplete remission during treatment. But still, the disease is chronic, serious and requires careful monitoring and treatment.
Answer #2
rapid muscle fatigue. You can live, but it’s very hard, probably
Answer #3
This is a congenital malignant change in the structure of the enzyme acetylcholinesterase, which is responsible for the breakdown of acetylcholine …. it seems so. It is the change in the structure of the enzyme itself that does not play any role, but the human immunity sounds the alarm against them and triggers apoptosis (programmed persecution and, as a result, self-destruction) of the enzyme, which plays a very important role in the life of the muscular system.
They manifest themselves in weakness and rapid muscle fatigue, which leads to general weakness of the body, periodic ptosis of the skin and internal cavities of organs (this is when they stretch and fall), for example, ptosis of the movable eyelid (stretching of the skin on the eyelids, like that of a wia, the intensity of which depends on emotional, physical state and time of day). Patients may suffocate and have heart problems.
Until the middle of the 20th century, the mortality rate from myasthenia gravis could reach 60%. But this is only due to unfavorable living conditions. Now if the disease is detected, it is successfully treated.
Women of average age (25-50 years) suffer more often. Children are very rare.
Answer #4
Myasthenia can be both congenital and acquired. The cause of congenital myasthenia is mutations in the genes of various proteins responsible for the construction and operation of neuromuscular synapses.
The disease usually begins at the age of 20-40 years; women are more often ill. Autoimmune processes play a role in the development mechanism of myasthenia, antibodies have been found in muscle tissue and the thymus gland. The muscles of the eyelids are often affected, ptosis appears, which varies in severity during the day; chewing muscles are affected, swallowing is disturbed, gait changes. It is harmful for patients to be nervous, as it causes chest pain and shortness of breath.
A provoking factor can be stress, an acute respiratory viral infection, a dysfunction of the body’s immune system leads to the formation of antibodies against the body’s own cells – against the acetylcholine receptors of the postsynaptic membrane of the neuromuscular junctions (synapses). Autoimmune myasthenia gravis is not inherited
; the disease is chronic, serious and requires careful monitoring and treatment.
Contraindications for myasthenia gravis
Excessive exercise
Insolation (limit exposure to direct sunlight
)
Curare-like muscle relaxants Neuroleptics and tranquilizers (except grandaxin ) ,
GHB
Diuretics (except veroshpiron and other spironolactones)
Antibiotics ciprofloxacin, ofloxacin, fleroxacin, lomefloxacin, sparfloxacin) and tetracycline under medical supervision Fluorine-containing corticosteroids (dexamethasone, dexazone, polcortolone) Quinine derivatives