Chronic nephritic syndrome

Chronic nephritic syndrome

Chronic nephritic syndrome is a syndrome that accompanies a number of diseases of various etiologies, characterized by diffuse glomerular sclerosis leading to CRF, clinically manifested by proteinuria, cylindruria, hematuria and arterial hypertension.


    • Focal and segmental sclerosis (28%)
    • Membranoproliferative glomerulonephritis (25%)
    • Glomerulonephritis with crescents (15%)
    • Membranous glomerulonephritis (4%). Pathomorphology
    • Increased extracellular material (mesangial matrix, glomerular basement membrane, collapsed capillary loops), glomerular synechia
    • Deposits of immunoglobulins in the glomeruli – a non-permanent sign
    • Interstitium lesions of varying degrees: tubular atrophy, sclerotic changes.

Clinical picture

    • The disease develops gradually and can be detected during an accidental medical examination.
    • Often there are no subjective complaints, recurrent episodes of proteinuria and hematuria are detected
    • The patient may have signs of uremia – nausea, vomiting, shortness of breath, itching, fatigue
    • Further, orthostatic edema and arterial hypertension, azotemia join.

Laboratory data

    • In the urine – proteinuria, hematuria, erythrocyte and hyaline cylinders
    • In the blood – an increase in the level of urea nitrogen and creatinine, anemia, metabolic acidosis, hyperphosphatemia and other signs of chronic renal failure. The diagnosis is confirmed by kidney biopsy.


    • Sodium Restricted Diet
    • Antihypertensive products
    • Treatment of HPN.


    • Chronic glomerulonephritis
    • Slowly progressive glomerular disease
    • Fibroplastic glomerulonephritis Nephritic syndrome, malignant nephrosclerosis. Verger’s disease, Chronic nephritic syndrome, Rapidly progressive nephritic syndrome. Acute nephritic syndrome, Chronic renal failure ICD. N03 Chronic nephritic syndrome



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