Hemolytic uremic syndrome

Hemolytic uremic syndrome

Hemolytic-uremic syndrome is a pathology of the kidneys that occurs with hemolytic anemia, thrombocytopenia and acute renal failure. They are observed mainly in babies, pregnant women and women in the postpartum period.

Etiopathogenesis

• • Infections (most likely Escherichia co//, 0157:H7). Endotoxemia triggers DIC with deposition of fibrin in the glomeruli and the development of acute renal failure
  • Reception of drugs
  • Mitomycin
  • Cyclosporine
  • Oral contraceptives.

Pathomorphology

• • Thrombosis of arterioles and capillaries of the glomerular apparatus
  • Fibrinoid necrosis of renal vessels
  • cortical necrosis.

clinical picture. Gastrointestinal bleeding, hematuria, oliguria and microangiopathic hemolytic anemia. Treatment is pathogenetic and symptomatic.

Forecast

• • In babies, it is favorable with adequate conservative treatment (including hemodialysis)
  • In adults, it is less favorable. It is determined by the functional state of the kidneys. Most patients with mitomycin-induced hemolytic uremic syndrome die of renal failure within a few months.

Synonyms

• • Gasser disease
  • Gasser syndrome
  • Gassera-Carrera

disease

ICD. D59.3 Hemolytic uremic syndrome