Indications for use:
The drug has antianginal (anti-ischemic) activity and is used to treat coronary heart disease. It is also effective in hypertension (persistent rise in blood pressure) (mainly in the early stages). In addition, nadolol is used to treat tachyarrhythmias (heart rhythm disturbances), migraines, and to relieve symptoms of hyperthyroidism (a disease caused by increased thyroid function).
Beta-adrenergic blocker of non-selective action (blocks beta and beta2-adrenergic receptors). It has a long duration of action. The half-life is 20-24 hours. It does not have a negative inotropic effect on the myocardium (does not reduce the strength of contractions of the heart muscle).
Nadolol (Nadolol) method of administration and doses:
Assign inside (in the form of tablets) regardless of the meal. Due to the long-term effect, it can be used 1 time (sometimes 2 times) a day.
In coronary heart disease, take starting from 40 mg 1 time per day. After 3-7 days, you can increase the dose to 80-160 mg per day (rarely up to 240 mg). The dose is adjusted depending on the effect; in case of excessive bradycardia (not frequent pulse), the dose is reduced. With hypertension (raising blood pressure), 40-80 mg is prescribed 1 time per day, gradually (at weekly intervals) the dose is increased to 240 mg per day (in 1-2 doses). You can simultaneously use diuretics (diuretics) or vasodilators (drugs that dilate blood vessels).
For the treatment of tachyarrhythmias, start with 40 mg every day, if necessary, the dose can be increased to 160 mg every day. With the appearance of bradycardia (decreased heart rate less than 50 beats per minute), the dose is reduced to 40 mg every day.
For the treatment of migraine and thyrotoxicosis, the dose range is 40-80-160 mg once every day.
As with other beta-blockers, the drug should be discontinued by gradually (over 2 weeks) lowering the dose.
Nadolol (Nadolol) contraindications:
The drug is contraindicated in bronchial asthma and a tendency to bronchospasm (sharp narrowing of the bronchial lumen), sinus bradycardia and heart block of 2-3 degrees (impaired conduction of excitation through the heart), cardiogenic shock, pulmonary hypertension (increased pressure in the vessels lungs), “congestive” heart defects. The product should not be administered to women during pregnancy and lactation. Caution is needed in renal and hepatic insufficiency, in diabetes mellitus.