It has antiarrhythmic (normalizing heart rate), antianginal (anti-ischemic) and hypotensive (lowering blood pressure) action. Reduces myocardial (heart muscle) oxygen demand by reducing myocardial contractility and slowing heart rate. It causes expansion of the coronary (heart) arteries and an increase in coronary blood flow. Reduces the tone of the smooth muscles of the peripheral arteries and the total peripheral vascular resistance (vascular resistance to blood flow). It has an antiarrhythmic effect in supraventricular arrhythmias (cardiac arrhythmias, in which the atria are the source of heart rhythm disturbances).
Gallopamil (Gallopamil) method of administration and dose:
Inside, 50 mg 2-4 times a day at intervals of at least 6 hours. The drug should be taken during or immediately after meals.
Gallopamil (Gallopamil) contraindications:
Severe bradycardia, sick sinus syndrome (heart disease, accompanied by a violation of the rhythm of its contractions), cardiogenic shock, atrioventricular blockade of 1I-III degree, Wolff-Parkinson-White syndrome (congenital heart disease, characterized by recurrent violation of the number and rhythm of heart contractions ), arterial hypotension, chronic heart failure PB-III stage, acute heart failure, severe liver and / or kidney dysfunction, pregnancy, lactation (breastfeeding), childhood, high susceptibility to the product.
Gallopamil (Gallopamil) side effects:
Nausea, dizziness, headache, flushing of the face, constipation are possible. In rare cases, nervousness, lethargy, high fatigue, allergic skin reactions are noted. When using large doses of the product, especially in predisposed patients, severe bradycardia (decreased heart rate), sinoauricular and / or atrioventricular blockade (disturbances in the conduction of excitation through the conduction system of the heart), arterial hypotension (lowering blood pressure), the appearance of symptoms of heart failure. Isolated cases of a transient (passing) increase in the blood activity of hepatic transaminases, alkaline phosphatase have been noted; development of intrahepatic cholestasis (stagnation of bile).