Combined product, relieves migraine attacks and headaches of vascular origin. Ergotamine normalizes the tone of dilated extracranial arteries. Caffeine accelerates and increases the absorption of ergotamine in the intestine.
After oral administration, ergotamine is absorbed in the gastrointestinal tract within 62%. The maximum plasma concentration is reached after 2 hours after oral administration. Plasma protein binding – 98%. Ergotamine is metabolized in the liver to pharmacologically active metabolites. Ergotamine is excreted mainly in the bile both unchanged and as metabolites. Elimination is biphasic, with half-lives of 2.7 hours and 21 hours for phases I and II, respectively.
After taking the substance inside, caffeine is absorbed quickly and almost completely. Plasma protein binding is 35%. Caffeine is almost completely metabolized in the body. Metabolites are excreted mainly in the urine. The half-life is within 3.5 hours.
Cafergot (Cafergot) method of administration and doses:
Cafergot should be taken at the very beginning of an attack. For the first dose, a dose of 2 tablets is recommended. If after 30 minutes there is no improvement in the condition, you should take another 1 tab. Reception of the product can be repeated further with an interval of 30 minutes, without exceeding the maximum daily dose.
In subsequent attacks, the initial dose can be increased to 3 tablets, depending on the total dose taken during previous attacks.
The maximum daily dose is 6 mg of ergotamine tartrate (6 tablets).
The maximum weekly dose is 10 mg of ergotamine tartrate (10 tablets).
Cafergot (Cafergot) contraindications:
– high susceptibility to one of the components of the product;
– violation of peripheral circulation;
– obliterating vascular diseases;
– ischemic heart disease or severe arterial hypertension;
– liver or kidney failure;
– pregnancy, lactation.
If symptoms such as numbness of the fingertips or feet appear, the product should be stopped immediately and consult a doctor.
Cafergot is used to treat an acute migraine attack and should not be used to prevent attacks or taken frequently for a long time.
Symptoms: nausea, vomiting, drowsiness, confusion, tachycardia, dizziness, paresthesia and pain in the limbs, respiratory depression, coma.
Treatment: gastric lavage, activated charcoal, symptomatic therapy, with atreria spasm – vasodilators such as sodium nitroprusside.
Co-administration of oleandomycin, erythromycin, or josamycin with ergotamine may result in increased plasma concentrations of ergotamine.
There are reports of several cases of vasospasm in patients treated simultaneously with ergotamine and propranolol.
Cafergot (Cafergot) side effects:
Nausea, vomiting, allergic reactions, increased blood pressure. With prolonged use – weakness and pain in the limbs, tremor, cardialgia, tachycardia, bradycardia, fibrotic changes in the pleura and retroperitoneal space. Overdose. Symptoms: drowsiness, confusion, tachycardia, dizziness, paresthesia, depression of the respiratory center, coma. Treatment: gastric lavage, activated charcoal, symptomatic therapy.