Hypotensive (lowering blood pressure) product. Inhibits (suppresses) the activity of angiotensin-converting enzyme, with the participation of which angiotensin I is converted into angiotensin II, which is the most active endogenous (formed in the body) pressor (increasing blood pressure) compound. By inhibiting the metabolism (transformations in the body) of bra-dikinin, the product also activates depressor (kinin) systems, with the participation of which vasodilating effects are realized.
Accupro (Akkupro) method of administration and doses:
The drug is prescribed for adults inside. Usually the initial dose is 0.01 g 1-2 times a day. If there is no normalization of blood pressure, the dose can be increased to 0.02 g per day. A further increase in dose can be made after 3 weeks. The maximum single dose is 0.02 g, the daily dose is 0.04 g.
The daily dose can be administered as a single dose or divided into 2 doses (morning and evening), regardless of food intake.
The duration of the course is determined individually.
The drug should be taken with caution under the supervision of a physician.
Accupro (Akkupro) contraindications:
Increased susceptibility to the product, tendency to edema, stenosis (narrowing) of the renal arteries, condition after kidney transplantation, narrowing of the aorta, narrowing of the mitral valve, myocardiopathy (heart disease of an unclear or controversial origin of a non-inflammatory nature), primary hyperaldosteronism (increased secretion of the hormone aldosterone due to hyperplasia or tumors of the adrenal cortex, accompanied by edema, fluid accumulation in the abdominal cavity, increased blood pressure), pregnancy, breastfeeding. Children under 14 years of age are not prescribed the product. Patients whose activities are associated with the need for a quick concentration of attention and a quick reaction (drivers of vehicles, operators, etc.) should be careful when treating with the product. You should refrain from alcohol during treatment with the drug.
Accupro (Akkupro) side effects:
Possible dizziness, headaches, orthostatic hypotension (drop in blood pressure when moving from a horizontal to a vertical position), heart rhythm disturbances, exacerbation of coronary heart disease and the brain, deterioration of peripheral circulation, sleep disturbances, tinnitus, nausea, diarrhea, cough, in rare cases – impaired renal function. Allergic reactions (skin, etc.) are possible, in some cases, the development of angioedema (allergic) edema; leukopenia (a decrease in the level of leukocytes in the blood), neutropenia (a decrease in the number of neutrophils in the blood), a decrease in hematocrit (the ratio of the volume of blood cells to plasma volume), eosinophilia (an increase in the number of eosins in the blood). Other side effects are also possible.